Preparative separation of methoxy derivatives of psoralen using supercritical-fluid chromatography. Russian Journal of Physical Chemistry B Volume 7, Issue 8, December 2013, Pages 901-915

14 сентября 2018
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Контактные данные автора публикации Pokrovskii, O.I.a , Krutikova, A.A.a, Ustinovich, K.B.a, Parenago, O.O.a, Moshnin, M.V.b, Gonchukov, S.A.b, Lunin, V.V.a ; a Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation b MEPhI
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Аннотация

A method of separation of a mixture of three methoxy derivatives of psoralen - bergapten, xanthotoxin, and isopimpinellin - has been developed. The performed screening allows it to be concluded that it is appropriate to separate them by normal-phase supercritical-fluid chromatography (SCF). Analysis of mechanisms of separation of methoxypsoralens (MOPs) showed that, on all silica gel-based sorbents with immobilized polar groups, except for 2-ethylpyridine and pentafluorophenyl sorbents, absorption occurs by the same retention mechanism. A possible explanation for the observed regularities of elution of the related MOPs has been suggested. In the case of pentafluorphenyl sorbent, π-electronic intermolecular interactions play a key role in separation. Presumably the same effect is responsible for the particular order of elution observed when the 2-ethypyridine sorbent was used.
Author keywords
furocoumarins; methoxypsoralens; retention mechanisms; supercritical-fluid chromatography
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