Study of biocompatibility and antitumor activity of lactic acid bacteria isolated from the human gastrointestinal tract

Objective: to study the biocompatibility of 17 strains of lactic acid bacteria previously isolated from the gastrointestinal tract of healthy people and people with oncological diseases. Methods: Lactic acid bacteria obtained from the digestive tract of healthy people and people with oncological diseases sick people from different age groups served as the basis of composing symbiotic consortia with a view to expand their effect. In vitro studies proved their inhibitory effect against lymphoma cell cultures, prostate cancer, breast cancer, hepatocellular carcinoma, brain cancer and pancreas cancer. Results: The paper established that biocompatibility of all group strains is characteristic of the Bifidobacterium breve and Lactobacillus casei strains, conditional biocompatibility can be identified in Lactobacillus fermentum, Lactobacillus plantarum, Lactobacillus acidophilus and Lactobacillus paracasei, respectively for the first and second groups. Biological incompatibility was observed in combinations: Bifidobacterium bifidum + Micrococcus spp.; Lactobacillus salivarius + Micrococcus spp. Conclusions: Study of antitumor properties of lactobacilli consortia composed of 17 previously selected probiotic strains demonstrate high antitumor activity of these consortia to cancer cell lines of Burkitts lymphoma (BRL2), human prostate cancer DU 145, human breast cancer MDAMB-231 and MCF7, hepatocellular carcinoma HepG2, brain cancer U-87, human pancreatic cancer PANC-1.